Risk stratification and long-term kidney survival in IgA nephropathy with particular emphasis on Oxford classification; A narrative review

Introduction: IgA nephropathy (IgAN) is one of the most common forms glomerulonephritis worldwide. It leads to end-stage renal disease (ESRD) in many patients. At time diagnosis, risk stratification paramount importance planning proper management individual cases. Several studies have been conducted determine utility various demographic, clinical, laboratory, and pathological features on biopsy stratify progression predict likely outcome. This review summarizes emerging data histological prognosis along with factors associated outcomes patients IgAN. Methods: For this review, we searched DOAJ (Directory Open Access Journals), PubMed/Medline, Web Science, Scopus, Embase, Google Scholar, using keywords including; "IgA nephropathy," nephritis," "IgAN," "Berger’s disease," syndrome," "chronic glomerulonephritis, "prognostic factors," "risk stratification," "renal survival," "ESRD," "MEST classification," "MEST-C classification" "Oxford Classification." To identify other relevant studies, manually scanned bibliographic lists identified reviewed articles from January 2009 through December 2020. All were carefully reviewed, information was extracted for narrative review. Results: A total 152 retrieved above literature database searches. The abstracts 35 containing prognostic longterm survival IgAN Relevant collected summarized main focus laboratory features, especially serial changes these parameters during follow-up, purpose. Recently a standardized, evidencebased formulation has devised evaluate categorize augment refine value traditional factors; it popularly known as Oxford classification There numerous validation ethnic groups that proven its clinical utility. Conclusion: In conclusion, clinicians should also take into account pathologic variables according revised addition early reliable prognostication at diagnosis optimal ultimate improvement long-term outcomes.